2019 基因體流行病學研習營

2019 Genomic Epidemiology Workshop

中研院基因體研究中心一樓演講廳

2019年8月5-9日

課程表

August 5th (Monday)

09:00-09:30 Opening Intrudction

09:30-10:30 Intro to NGS Technologies

10:30-10:45 Break

10:45-12:00 Intro to long-read Technologies

12:00-13:00 Lunch

13:00-14:00 NGS data format and analysis flow

14:00-14:15 Break

14:15-15:30 (hands on) FASTQC and Alignment

15:30-15:45 Break

15:45-17:00 (hands on) INDEL/CNV/SV calling

August 6th (Tuesday)

09:00-10:30 Annotational for clinical

10:30-10:45 Break

10:45-12:00 Intro to RNASeq Experiment Design

12:00-13:00 Lunch

13:00-14:00 RNASeq Alignment, Quantification, Normalization

14:00-14:15 Break

14:15-15:30 RNASeq Analysis

15:30-15:45 Break

15:45-17:00 RNASeq Analysis

August 7th (Wednesday)

09:00-10:15 GWAS intoduction

▪ Study design

▪ Genetic variations /QC / imputation

10:15-10:45 Break

10:45-12:00 Analysis theory

▪ Common variants association

▪ Single variant meta-analysis

12:00-13:00 Lunch

13:00-14:30 Advanced analyses

▪ Polygenic score prediction

▪ Mendelian Randomization

14:30-15:00 Break

15:00-17:00 GWAS

▪ SNP-based heritability

▪ SNP-based genetic correlation; LD Hub

18:00-20:00 Panel Discussion & Dinner

August 8th (Thursday)

09:00-10:15 Association analysis practice

▪ GWAS QC and association analysis: Part 1

10:15-10:45 Break

10:45-12:00 Association analysis practice

▪ GWAS QC and association analysis: Part 2

12:00-13:00 Lunch

13:00-14:30 Data Base, Biobanks and Online Resources:

TopMed, TCGA, GTEX, UKBIOBANK, etc….

14:30-15:00 Break

15:00-17:00 Funcitonal Genomics, AI machine learning deep learning

August 9th (Friday)

09:00-10:15 Epigenetics

Introduction to epigenetics concepts

10:15-10:45 Break

10:45-12:00 Methylations

▪ Case Study and Additional tools

12:00-13:00 Lunch

13:00-14:30 Methylations

▪ Mediation analysis and repeated measurements

14:30-15:00 Break

15:00-16:30 Microbiome

16:30-17:00 Q&A and Feedback